Thermal Stability Threshold for Amyloid Formation in Light Chain Amyloidosis
نویسندگان
چکیده
منابع مشابه
Thermal Stability Threshold for Amyloid Formation in Light Chain Amyloidosis
Light chain (AL) amyloidosis is a devastating disease characterized by amyloid deposits formed by immunoglobulin light chains. Current available treatments involve conventional chemotherapy and autologous stem cell transplant. We have recently concluded a phase III trial comparing these two treatments. AL amyloidosis patients who achieve hematological complete response (CR) do not necessarily a...
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Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary presenting complaint was of lon...
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A previously healthy 50-year-old man presented to his primary care physician with fatigue. Screening blood tests revealed a bilirubin level of 14 μmol/L (0.82 mg/dL), an aspartate aminotransferase (AST) level of 57 IU/L, an alkaline phosphatase (ALP) level of 72 IU/L, a g-glutamyltranspeptidase level of 126 IU/L, an albumin level of 30 g/L, and hypercholesterolemia. Results from hepatitis B and...
متن کاملDirect Factor X sequestration by systemic amyloid light‐chain amyloidosis
We present a lymphoplasmacytic lymphoma patient with Factor X (FX) deficiency. Despite the absence of FX inhibitor, the administration of fresh frozen plasma and anti-inhibitor coagulant complex did not increase the FX level. The autopsy showed that massive amyloid depositions to multiple organs and FX existed in union with amyloidosis.
متن کاملLight Chain Amyloidosis
Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to produce the amyloidogenic light chains. They are able to misfold and aggregate, deposit in tissues in the form of amyloid fibrils and lead to irreversible organ dysfunction and eventually death if treatment is late or ineffective. Cardiac damage is the most important prognostic determinant. The risk of d...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2013
ISSN: 1422-0067
DOI: 10.3390/ijms141122604